Optimal control and cost-effectiveness analysis of a Zika virus infection model with comprehensive interventions

作者：

Highlights：

• We study a Zika model with two transmission modes and comprehensive interventions.

• We perform sensitivity test of the basic reproduction number on each control.

• We formulate and solve the optimal control problem of the Zika model.

• Using the cost effectiveness analysis, we obtain the most cost-effective strategy.

摘要

•We study a Zika model with two transmission modes and comprehensive interventions.•We perform sensitivity test of the basic reproduction number on each control.•We formulate and solve the optimal control problem of the Zika model.•Using the cost effectiveness analysis, we obtain the most cost-effective strategy.

论文关键词：Zika,Mosquito-to-human transmission,Human-to-human transmission,Basic reproduction number,Sensitivity analysis,Cost-effectiveness,Optimal control

论文评审过程：Received 23 July 2018, Revised 18 December 2018, Accepted 8 April 2019, Available online 11 May 2019, Version of Record 11 May 2019.

论文官网地址：https://doi.org/10.1016/j.amc.2019.04.026