Significance of antiviral therapy and CTL-mediated immune response in containing hepatitis B and C virus infection

作者：

Highlights：

• The model HBV/HCV dynamics that incorporates CTL-mediated immune response and antiviral therapy is developed and analysed.

• Sensitivity and significance of specific parameters is examined as well as pairwise comparison of significant parameters while accounting for False Discovery rate adjustment.

• The infection is characterised by recurring episodes of the problem although with decreasing intensity.

• Highly effective antiviral therapy of at least 80% efficacy is essential in containing the infection.

摘要

•The model HBV/HCV dynamics that incorporates CTL-mediated immune response and antiviral therapy is developed and analysed.•Sensitivity and significance of specific parameters is examined as well as pairwise comparison of significant parameters while accounting for False Discovery rate adjustment.•The infection is characterised by recurring episodes of the problem although with decreasing intensity.•Highly effective antiviral therapy of at least 80% efficacy is essential in containing the infection.

论文关键词：Hepatitis B/C virus,Immune response,Antiviral therapy,Sensitivity analysis,Pairwise comparison

论文评审过程：Received 9 May 2020, Revised 25 October 2020, Accepted 19 December 2020, Available online 12 January 2021, Version of Record 12 January 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2020.125926