Mathematical analysis of the impact of transmission-blocking drugs on the population dynamics of malaria

作者：

Highlights：

• A mathematical model that takes into account an intervention using transmission-blocking drugs (TBDs) is proposed and analyzed.

• Potential effects of transmission-blocking drugs on malaria transmission are studied.

• Mathematical assessment of treatment coverage and efficacy of TBDs are presented.

• The model exhibits a backward bifurcation.

• The projections of the validated model using data show the benefits of using TBDs in malaria control in preventing new cases and reducing mortality.

摘要

•A mathematical model that takes into account an intervention using transmission-blocking drugs (TBDs) is proposed and analyzed.•Potential effects of transmission-blocking drugs on malaria transmission are studied.•Mathematical assessment of treatment coverage and efficacy of TBDs are presented.•The model exhibits a backward bifurcation.•The projections of the validated model using data show the benefits of using TBDs in malaria control in preventing new cases and reducing mortality.

论文关键词：Transmission-blocking antimalarial drug,Mathematical modeling,Data fitting,Treatment coverage,Drug efficacy,Bifurcation analysis,Numeral simulation

论文评审过程：Received 13 August 2020, Revised 9 November 2020, Accepted 17 January 2021, Available online 23 February 2021, Version of Record 23 February 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126005