A within-host virus model with multiple infected stages under time-varying environments

作者：

Highlights：

• We propose a within-host virus model with multiple infected stages under time-varying environments.

• We establish the sufficient conditions for both persistent HIV infection and clearance of HIV infection.

• We extend the results for the related within-host model with single infected stage.

• We generalize the works for corresponding autonomous within-host system with multiple infected stages.

摘要

•We propose a within-host virus model with multiple infected stages under time-varying environments.•We establish the sufficient conditions for both persistent HIV infection and clearance of HIV infection.•We extend the results for the related within-host model with single infected stage.•We generalize the works for corresponding autonomous within-host system with multiple infected stages.

论文关键词：Time-varying,Multiple infected stages,Within-host virus model,Permanence and extinction,Viral load

论文评审过程：Received 28 October 2014, Revised 3 March 2015, Accepted 10 May 2015, Available online 2 June 2015, Version of Record 2 June 2015.

论文官网地址：https://doi.org/10.1016/j.amc.2015.05.033