A quantitative image analysis for the cellular cytoskeleton during in vitro tumor growth

作者:

Highlights:

• A quantitative image analysis method to quantify cellular cytoskeleton changes.

• The method segments cell parts using maker-controlled watershed segmentation.

• Morphological operation, distance transform and post-processing play important roles.

• Two texture analysis methods quantify several cytoskeletal features in tumor.

• It can be used to test different biological hypothesis using cellular image sample.

摘要

•A quantitative image analysis method to quantify cellular cytoskeleton changes.•The method segments cell parts using maker-controlled watershed segmentation.•Morphological operation, distance transform and post-processing play important roles.•Two texture analysis methods quantify several cytoskeletal features in tumor.•It can be used to test different biological hypothesis using cellular image sample.

论文关键词:Cellular cytoskeleton,Maspin,Tumor growth,Quantitative image analysis,Marker-controlled watershed segmentation Texture analysis

论文评审过程:Received 21 January 2017, Revised 23 July 2017, Accepted 29 August 2017, Available online 6 September 2017, Version of Record 22 September 2017.

论文官网地址:https://doi.org/10.1016/j.eswa.2017.08.048