A multi-objective production planning problem with the consideration of time and cost in clinical trials

作者：

Highlights：

• The proposed algorithm gives better solutions than the direct solution approach.

• The operational cost decreases with the increase of the production quantity.

• We quantify the tradeoff between the duration and the total cost of clinical trials.

• The tradeoff can be used to determine the optimal production quantity.

摘要

•The proposed algorithm gives better solutions than the direct solution approach.•The operational cost decreases with the increase of the production quantity.•We quantify the tradeoff between the duration and the total cost of clinical trials.•The tradeoff can be used to determine the optimal production quantity.

论文关键词：Supply chain management,Clinical trial,Production and distribution planning,Multi-stage stochastic programming,Progressive hedging algorithm

论文评审过程：Received 14 April 2018, Revised 6 October 2018, Accepted 10 January 2019, Available online 11 January 2019, Version of Record 23 January 2019.

论文官网地址：https://doi.org/10.1016/j.eswa.2019.01.038