Detecting retinal vasculature as a key biomarker for deep Learning-based intelligent screening and analysis of diabetic and hypertensive retinopathy

摘要

Retinal vessels are considered important biomarkers for the detection of retinal diseases, like diabetic retinopathy (caused by diabetes) and hypertensive retinopathy (caused by hypertension). The manual finding from this retinal vasculature is time-consuming and costly. The image quality of the fundus image directly affects the accurate segmentation of these vessels in the automatic methods. With such inferior quality images, deep-learning-based methods are better for dealing with segmentation. Conventional deep-learning-based vessel segmentation methods deal the segmentation task with deeper convolutional neural networks and many trainable parameters. Minor changes in the retinal vasculature, such as those that result from the creation of new smaller vessels, is crucial for the keen analysis of diseases (e.g., diabetic retinopathy). The small vessels are crucial to segment, owing to continuous max-pooling operations and deeper networks. We herein present a pool-less residual segmentation network that is capable of segmenting even smaller vessels using a shallower network with a low number of trainable parameters. Our proposed pool-less residual segmentation network (PLRS-Net) is a vessel segmentation network that provides the pooling effect with strided convolution for better segmentation sensitivity. The final PLRS-Net is an advanced form of a pool-less segmentation network (PLS-Net) wherein semantic segmentation was performed with a few layers, and the residual connection fulfilled the feature enhancement strategy to construct PLRS-Net. PLS-Net and PLRS-Net are two separate networks that can perform vessel segmentation without prior preprocessing and postprocessing.To evaluate our proposed method, the experiments include three publicly available datasets: Digital retinal images for vessel extraction (DRIVE), child heart health study in England database (CHASE-DB1), and structured analysis of retina (STARE). The results demonstrate that our proposed method provides a high segmentation performance, achieving an average sensitivity (Sen) of 82.69, specificity (Spe) of 98.17, accuracy (Acc) 96.82, and area under the curve (AUC) of 98.35 for the DRIVE dataset, Sen of 83.01, Spe of 98.39, Acc of 97.31, and AUC of 98.63 for the CHASE-DB1 dataset, and a Sen of 86.35, Spe of 98.03, Acc of 97.15, and AUC of 98.99 for the STARE dataset. These accuracies show exceptional segmentation performance of the proposed method compared to state-of-the-art approaches for automatic vessel detection for diagnosis purposes.