The cellular automata model for lipid membranes

摘要

Three models of the effect of amphiphilic molecules on lipid membranes were studied by the cellular automata method. Different types of molecular aggregation based on different affinity of the interacting molecules, depending on their “head” and alkyl chain length, are proposed to explain the differences in permeability of a lipid membrane modified with a mixture of amphiphilic cationic and anionic modifiers. It was shown within these models that a mixture of oppositely charged amphiphilic molecules can increase the permeability of a membrane modified with only one type of modifier when the mixture contains long and short alkyl chain amphiphiles and can decrease it in the case when all modifier molecules have long alkyl chains. These results are compared with experimental data.