Use of mathematical model for effectivity estimation of HIV infection therapies

摘要

The previously developed mathematical model simulates the CD4+ lymphocyte dynamics in HIV infection considerably well. As the number of these cells is a good indicator of the infection progression, it was used to evaluate the effectivity of different therapeutic interventions. For chemotherapy simulation, both permanent and temporary AZT administration was considered and the induced return of the CD4+ lymphocyte counts was analyzed. Similar analysis was performed for active and passive immunotherapy. The model offers also the possibility of simulating the CD4+ dynamics after depletion of CD8+ lymphocytes by antibodies. Even one simulated administration of anti-CD8 antibodies increases the CD4+ lymphocyte counts and prolongs the patient survival. However, if cells involved in protective immunity are assumed to belong to the CD8+ category, anti-CD8 antibodies accelerate the decrease of CD4+ cells and thus shorten the patient survival.