Dynamics of tumor–CD4+–cytokine–host cells interactions with treatments

作者：

Highlights：

• Models of interactions between tumor and immune system are studied.

• There is window of opportunity for clear off tumor due to bistability.

• Host cells and mechanism of CD4 production are critical in regulating tumor dynamics.

摘要

•Models of interactions between tumor and immune system are studied.•There is window of opportunity for clear off tumor due to bistability.•Host cells and mechanism of CD4 production are critical in regulating tumor dynamics.

论文关键词：Tumor,Immunotherapy,Cytokine,Ordinary differential equations,Global stability,Bistability

论文评审过程：Received 18 March 2017, Revised 2 November 2017, Accepted 5 November 2017, Available online 1 December 2017, Version of Record 1 December 2017.

论文官网地址：https://doi.org/10.1016/j.amc.2017.11.009