Global dynamics of SARS-CoV-2/cancer model with immune responses

作者：

Highlights：

• A new SARS-CoV-2/cancer model is developed and rigorously analyzed.

• Cancer-specific CTLs and SARS-CoV-2-specific antibodies have been considered.

• Well-possedness of the model and existence of equilibria are established.

• Global stability of the equilibria is established by means of Lyapunov functions.

• We have presented numerical simulations to illustrate the effectiveness of our main results.

• We have discussed the effect of lymphopenia on SARS-CoV-2/cancer patients.

摘要

•A new SARS-CoV-2/cancer model is developed and rigorously analyzed.•Cancer-specific CTLs and SARS-CoV-2-specific antibodies have been considered.•Well-possedness of the model and existence of equilibria are established.•Global stability of the equilibria is established by means of Lyapunov functions.•We have presented numerical simulations to illustrate the effectiveness of our main results.•We have discussed the effect of lymphopenia on SARS-CoV-2/cancer patients.

论文关键词：COVID-19,SARS-CoV-2,Cancer,Lymphopenia,Immune response,Global stability

论文评审过程：Received 5 October 2020, Revised 3 April 2021, Accepted 5 May 2021, Available online 12 May 2021, Version of Record 26 May 2021.

论文官网地址：https://doi.org/10.1016/j.amc.2021.126364