Mathematical model of Alzheimer’s disease with prion proteins interactions and treatment

作者：

Highlights：

• Studied an Alzheimer’s disease model with discrete sizes and two types of Aβ, the interaction with Prpc as well as the treatment.

• Proved the global asymptotic stability.

• Presented numerical simulations and investigate the contributions from two types of Aβ.

• Explained Aβ42 paranuclei can be used as a therapeutic target.

摘要

•Studied an Alzheimer’s disease model with discrete sizes and two types of Aβ, the interaction with Prpc as well as the treatment.•Proved the global asymptotic stability.•Presented numerical simulations and investigate the contributions from two types of Aβ.•Explained Aβ42 paranuclei can be used as a therapeutic target.

论文关键词：Alzheimer’s disease,Prion proteins,Two types of Aβ,Anti-Aβ drugs treatment,Globally asymptotically stable

论文评审过程：Received 12 October 2021, Revised 1 July 2022, Accepted 2 July 2022, Available online 18 July 2022, Version of Record 18 July 2022.

论文官网地址：https://doi.org/10.1016/j.amc.2022.127377