Analysis of a model for the propagation of the ossification front

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In this paper, we study a model for the propagation of the ossification front. This is written as a parabolic nonlinear partial differential equation in terms of the density of the osteogenic cells. Its variational formulation leads to a parabolic nonlinear variational equation for which an existence and uniqueness result is proved. Then, we introduce a fully discrete approximation by using the finite element method for the spatial approximation and a Euler scheme to discretize the time derivatives. A priori error estimates are obtained from which, under adequate additional regularity conditions, the linear convergence is derived. Finally, some numerical simulations are shown to demonstrate the accuracy and the influence of the approximation.

论文关键词:Ossification front,Osteogenic cells,Finite elements,A priori estimates,Numerical simulations

论文评审过程:Received 21 July 2015, Revised 16 September 2015, Available online 10 November 2015, Version of Record 27 January 2017.

论文官网地址:https://doi.org/10.1016/j.cam.2015.10.032