The impact of pre-exposure prophylaxis (PrEP) and screening on the dynamics of HIV

作者：

Highlights：

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• A non-integer order model is derived to assess the impact of PrEP and HCT on the dynamics of HIV infection.

• The screening efficacy, rather than the screening rate, provides better outcomes, with respect to HIV transmission.

• Fractional models may be powerful tools to analyze HIV dynamics.

• Biologically, non-integer order derivatives may help distinguish patients’ sexual behaviours.

摘要

•A non-integer order model is derived to assess the impact of PrEP and HCT on the dynamics of HIV infection.•The screening efficacy, rather than the screening rate, provides better outcomes, with respect to HIV transmission.•Fractional models may be powerful tools to analyze HIV dynamics.•Biologically, non-integer order derivatives may help distinguish patients’ sexual behaviours.

论文关键词：PrEP,HCT,HIV,Fractional model

论文评审过程：Received 7 July 2017, Revised 11 October 2017, Available online 1 November 2017, Version of Record 18 April 2018.

论文官网地址：https://doi.org/10.1016/j.cam.2017.10.019