Symptoms and medications change patterns for Parkinson's disease patients stratification

作者：

Highlights：

• Parkinson's disease progression and medication changes for improved quality of life.

• New algorithm for determining how symptoms influence patients’ overall status.

• Detected possible early indicators of Parkinson's disease progression.

• Multitask learning to determine trigger symptoms for therapy change.

• Detected subgroups of patients treated with different therapy modifications.

摘要

•Parkinson's disease progression and medication changes for improved quality of life.•New algorithm for determining how symptoms influence patients’ overall status.•Detected possible early indicators of Parkinson's disease progression.•Multitask learning to determine trigger symptoms for therapy change.•Detected subgroups of patients treated with different therapy modifications.

论文关键词：Parkinson's disease,Analysis of disease progression,Multitask learning,Analysis of medications treatment,Symptoms impact

论文评审过程：Received 31 October 2017, Revised 26 April 2018, Accepted 30 April 2018, Available online 24 May 2018, Version of Record 6 November 2018.

论文官网地址：https://doi.org/10.1016/j.artmed.2018.04.010