Computational methods for Gene Regulatory Networks reconstruction and analysis: A review

作者：

Highlights：

• The inference of Gene Regulatory Networks enables the integrative analysis of biological systems.

• Novel computational approaches have been developed for network reconstruction and evaluation.

• Gene Network validation still remains a challenging step of the process.

• This review presents a comprehensive review of the field.

摘要

•The inference of Gene Regulatory Networks enables the integrative analysis of biological systems.•Novel computational approaches have been developed for network reconstruction and evaluation.•Gene Network validation still remains a challenging step of the process.•This review presents a comprehensive review of the field.

论文关键词：Gene Network,Systems biology,Networks validation,Gene Regulatory Network,Gene Network inference

论文评审过程：Received 21 June 2018, Revised 23 October 2018, Accepted 23 October 2018, Available online 9 November 2018, Version of Record 20 March 2019.

论文官网地址：https://doi.org/10.1016/j.artmed.2018.10.006