Fuzzy genomes

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摘要

A metric space — dubbed the fuzzy polynucleotide space — is presented for diagnostic purposes in the widest sense to measure the degree of difference and similarity between sequences of nucleic acids. To this end, these acids are transformed to ordered fuzzy sets. They thus become representable as points in n-dimensional unit hypercubes that may be endowed with various metrics. In this way, genetic information in particular and genetics in general become amenable to fuzzy theory, geometry, and topology.

论文关键词:Genome,Nucleic acids,Base sequence,Genetic diagnosis,Polynucleotides,Fuzzy hypercube,Fuzzy polynucleotide space,Similarity,Dissimilarity,Polymers

论文评审过程:Accepted 6 August 1999, Available online 17 December 1999.

论文官网地址:https://doi.org/10.1016/S0933-3657(99)00032-9